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2019

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cc-by (c) Hernáez Camba, Álvaro et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/158943

Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination

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https://doi.org/10.1371/journal.pone.0218533

Resum

Background High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. Objective To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. Methods In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. Results Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). Conclusions Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity. © 2019 Hernáez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Matèries

Colesterol, Lipoproteïnes, Oxidació

Matèries (anglès)

Cholesterol, Lipoproteins, Oxidation

Citació

Col·leccions

Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

HERNÁEZ CAMBA, Álvaro, SORIA FLORIDO, María trinidad, SCHRÖDER, Helmut, ROS RAHOLA, Emilio, PINTÓ SALA, Xavier, ESTRUCH RIBA, Ramon, SALAS SALVADÓ, Jordi, CORELLA PIQUER, Dolores, ARÓS, Fernando, SERRA MAJEM, Lluís, MARTÍNEZ-GONZÁLEZ, Miguel ángel, FIOL SALA, Miguel, LAPETRA, José, ELOSUA, Roberto, LAMUELA RAVENTÓS, Rosa ma., FITÓ COLOMER, Montserrat. Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination. _PLoS One_. 2019. Vol. 14, núm. 6, pàgs. e0218533. [consulta: 21 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/158943]

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