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2011-07-01

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/44734

Tuberous sclerosis complex with oral manifestations: A case report and literature review

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Abstract

Introduction: Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome produced by a number of genetic mutations. The disease is characterized by the development of benign tumors affecting different body systems. The most common oral manifestations of TSC are fibromas, gingival hyperplasia and enamel hypoplasia. Clinical Case: A 35-year-old woman diagnosed with TSC presented with a reactive fibroma of considerable size and rapid growth in the region of the right lower third molar. Discussion: In the present case the association of TSC with dental malpositioning gave rise to a rapidly evolving reactive fibroma of considerable diameter. Few similar cases can be found in the literature. Patients with TSC present mutations of the TSC1 and TSC2 genes, which intervene in cell cycle regulation and are important for avoiding neoplastic processes. No studies have been found associating TSC with an increased risk of oral cancer, though it has been shown that the over-expression of TSC2 could exert an antitumor effect. Careful oral and dental hygiene, together with regular visits to the dentist, are needed for the prevention and early detection of any type of oral lesion. The renal, pulmonary and cardiac alterations often seen in TSC must be taken into account for the correct management of these patients.

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http://dx.doi.org/doi:10.4317/medoral.16.e478

Subject

Tumors, Malalties de la boca, Esclerosi tuberosa, Fibromes

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Tumors, Mouth diseases, Tuberosis sclerosis

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Articles publicats en revistes (Odontoestomatologia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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HARUTUNIAN, Karmen, BARBOSA DE FIGUEIREDO, Rui Pedro and GAY ESCODA, Cosme. Tuberous sclerosis complex with oral manifestations: A case report and literature review. Medicina Oral. Patología Oral y Cirugia Bucal. Vol.  2011, num. 16, pags. 4. ISSN 1698-4447. [consulted: 10 of October of 2026]. Available at: https://hdl.handle.net/2445/44734

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