Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/192701
Non-G Base Tetrads
Journal Title
Director/Tutor
Additional contribution
Journal ISSN
Volume Title
Abstract
Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most extensively studied guanine quadruplex (G-quadruplex). Consequently, the G-tetrad is the most common and well-known tetrad. However, this is not the only possible arrangement of four nucleobases. A number of tetrads formed by the different nucleobases have been observed in experimental structures. In most cases, these tetrads occur in the context of G-quadruplex structures, either inserted between G-quartets, or as capping elements at the sides of the G-quadruplex core. In other cases, however, non-G tetrads are found in more unusual four stranded structures, such as i-motifs, or different types of peculiar fold-back structures. In this report, we review the diversity of these non-canonical tetrads, and the structural context in which they have been found.
Related resource
Citation
Citation
ESCAJA SÁNCHEZ, Nuria, et al. Non-G Base Tetrads. Molecules. 2022. Vol. 27, num. 16, pags. 5287. ISSN 1420-3049. [consulted: 12 of October of 2026]. Available at: https://hdl.handle.net/2445/192701