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The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures

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dc.contributor.authorMir Morro, Bartomeu
dc.contributor.authorSolés, X.
dc.contributor.authorGonzález, Carlos
dc.contributor.authorEscaja Sánchez, Nuria
dc.date.accessioned2017-06-14T13:53:09Z
dc.date.available2017-06-14T13:53:09Z
dc.date.issued2017-06-05
dc.date.updated2017-06-14T13:53:10Z
dc.description.abstractIncorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure.
dc.format.extent8 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec672099
dc.identifier.issn2045-2322
dc.identifier.pmid28584239
dc.identifier.urihttps://hdl.handle.net/2445/112375
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41598-017-02723-y
dc.relation.ispartofScientific Reports, 2017, vol. 7, num. 2772
dc.relation.urihttps://doi.org/10.1038/s41598-017-02723-y
dc.rightscc-by (c) Mir Morro, Bartomeu et al., 2017
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationÀcids nucleics
dc.subject.classificationCitidina difosfat de colina
dc.subject.classificationOligonucleòtids
dc.subject.otherNucleic acids
dc.subject.otherCytidine diphosphate choline
dc.subject.otherOligonucleotides
dc.titleThe effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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