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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/112375
The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures
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Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure.
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MIR MORRO, Bartomeu, et al. The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures. Scientific Reports. 2017. Vol. 7, num. 2772. ISSN 2045-2322. [consulted: 11 of October of 2026]. Available at: https://hdl.handle.net/2445/112375