Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/229063
Cyclometallated iridium(iii) complexes: ligand-driven selectivity for chemotherapy and photodynamic therapy
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This study explores two cyclometallated Ir(III) complex families with distinct therapeutic profiles. Benzothiophene derivatives (1, 2) exhibit potent antiproliferative character in the dark, favoring chemotherapy, while benzothiazole analogs (3 and 4) show high photocytotoxicity, ideal for photodynamic therapy. Photophysical studies and subcellular localization analyses highlight ligand-driven selectivity and the role of organelle targeting in therapeutic outcomes.
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MORALES-PIOZ, Eva, et al. Cyclometallated iridium(iii) complexes: ligand-driven selectivity for chemotherapy and photodynamic therapy. Chemical Communications. 2025. Vol. 61, num. 97, pags. 19237-19240. ISSN 1359-7345. [consulted: 14 of June of 2026]. Available at: https://hdl.handle.net/2445/229063