Cyclometallated iridium(iii) complexes: ligand-driven selectivity for chemotherapy and photodynamic therapy

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dc.contributor.authorMorales-Pioz, Eva
dc.contributor.authorGarcía Orduña, Pilar
dc.contributor.authorRedrado, Marta
dc.contributor.authorBenedi Visiedo, Andrea
dc.contributor.authorRoyo Cañas, Maria
dc.contributor.authorde Aquino Samper, Araceli de
dc.contributor.authorGodino, Javier
dc.contributor.authorMarzo, Isabel
dc.contributor.authorRodríguez Raurell, Laura
dc.contributor.authorGimeno, M. Concepción
dc.contributor.authorFernández-Moreira, Vanesa
dc.date.accessioned2026-04-20T12:10:32Z
dc.date.issued2025-11-05
dc.date.updated2026-04-20T12:10:33Z
dc.description.abstractThis study explores two cyclometallated Ir(III) complex families with distinct therapeutic profiles. Benzothiophene derivatives (1, 2) exhibit potent antiproliferative character in the dark, favoring chemotherapy, while benzothiazole analogs (3 and 4) show high photocytotoxicity, ideal for photodynamic therapy. Photophysical studies and subcellular localization analyses highlight ligand-driven selectivity and the role of organelle targeting in therapeutic outcomes.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec766678
dc.identifier.issn1359-7345
dc.identifier.urihttps://hdl.handle.net/2445/229063
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1039/D5CC04768D
dc.relation.ispartofChemical Communications, 2025, vol. 61, num.97, p. 19237-19240
dc.relation.urihttps://doi.org/10.1039/D5CC04768D
dc.rightscc-by nc (c) Morales-Pioz, E. et al., 2025
dc.rights.accessRightsinfo:eu-repo/semantics/OpenAccess
dc.rights.uricc by-nc https://creativecommons.org/li censes/by-nc/3.0/
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationQuimioteràpia
dc.subject.otherChemotherapy
dc.titleCyclometallated iridium(iii) complexes: ligand-driven selectivity for chemotherapy and photodynamic therapy
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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