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Microwave-Assisted Synthesis of Substituted Pyrrolo[2,3-d]pyrimidines
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A new synthetic routes to the triaryl pyrrolo[2,3-d]pyrimidines from common 4,6-dichloropyrimidine have been developed. The triarylated compounds are synthesized by three cross-coupling reactions using three different catalysts. The introduction of C-6-aryl was allowed in two step process using Sonogashira conditions followed by intramolecular cyclization and the Suzuki-Miyaura conditions led the C-4 and C-5 diarylation. This sequence allows a flexible approach to the highly arylated pyrrolopyrimidines containing different aryl groups
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PRIEUR, Vanessa, et al. Microwave-Assisted Synthesis of Substituted Pyrrolo[2,3-d]pyrimidines. European Journal of Organic Chemistry. 2014. Vol. 2014, num. 7, pags. 1514-1524. ISSN 1434-193X. [consulted: 23 of June of 2026]. Available at: https://hdl.handle.net/2445/165543