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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/126610
Epigenetic Regulation of miR-212 Expression in Lung Cancer
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Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.
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INCORONATO, Mariarosaria, et al. Epigenetic Regulation of miR-212 Expression in Lung Cancer. PLoS One. 2011. Vol. 6, num. 11, pags. e27722. [consulted: 15 of October of 2026]. Available at: https://hdl.handle.net/2445/126610