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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/162874
Combined Virtual/Experimental Multicomponent Solid Forms Screening of Sildenafil: New Salts, Cocrystals, and Hybrid Salt−Cocrystals
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New multicomponent solid forms of sildenafil have been discovered by means of a combined virtual/experimental cocrystal screening. Coformer selection of candidates was conducted based on an in silico screening method from a database of more than 2000 organic compounds, and the intensive experimental screen produced 23 new solid forms. Since the 12 coformers chosen have a combination of phenol and carboxylic acid groups, a variety of cocrystals, salts, and hybrid salt-cocrystals were discovered and characterized.
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BARBAS CAÑERO, Rafael, FONT BARDIA, Ma. mercedes, PARADKAR, A., HUNTER, C. a., PROHENS LÓPEZ, Rafael. Combined Virtual/Experimental Multicomponent Solid Forms Screening of Sildenafil: New Salts, Cocrystals, and Hybrid Salt−Cocrystals. _Crystal Growth & Design_. 2018. Vol. 18, núm. 12, pàgs. 7618-7627. [consulta: 14 de gener de 2026]. ISSN: 1528-7483. [Disponible a: https://hdl.handle.net/2445/162874]