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s13287-021-02301-0.pdf (2.21 MB)

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2021-04-13

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cc by (c) Álvarez Palomo et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/176988

Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells

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https://doi.org/10.1186/s13287-021-02301-0

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Background: iPSC (induced pluripotent stem cells) banks of iPSC lines with homozygous HLA (human leukocyte antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplantation of iPSC derived cell therapies. Cord blood banks offer an extensive source of HLA-typed cells suitable for reprogramming to iPSC. Several initiatives worldwide have been undertaken to create national and international iPSC haplobanks that match a significant part of a population. Methods: To create an iPSC haplobank that serves the Spanish population (IPS-PANIA), we have searched the Spanish Bone Marrow Donor Registry (REDMO) to identify the most frequently estimated haplotypes. From the top ten donors identified, we estimated the population coverage using the criteria of zero mismatches in HLA-A, HLA-B, and HLA-DRB1 with different stringencies: high resolution, low resolution, and beneficial mismatch. Results: We have calculated that ten cord blood units from homozygous donors stored at the Spanish cord blood banks can provide HLA-A, HLA-B, and HLA-DRB1 matching for 28.23% of the population. Conclusion: We confirm the feasibility of using banked cord blood units to create an iPSC haplobank that will cover a significant percentage of the Spanish and international population for future advanced therapy replacement strategies.

Matèries

Cèl·lules mare, Cordó umbilical

Matèries (anglès)

Stem cells, Umbilical cord

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

ÁLVAREZ PALOMO, Belén, GARCÍA MARTÍNEZ, Iris, GAYOSO, Jorge, RAYA CHAMORRO, Ángel, VEIGA, Anna, ABAD, María lluisa, EIRAS, Adolfo, GUZMÁN FULGENCIO, María, LUIS HIDALGO, Mar, EGUIZÁBAL, Cristina, SANTOS, Silvia, BALAS, Antonio, ALENDA, Raquel, SÁNCHEZ GORDO, Francisco, PONCE VERDUGO, Laura, VILLA, Juliana, CARRERAS, Enric, VIDAL, Francisco, MADRIGAL, Alejandro, HERRERO, María josé, RUDILLA SALVADOR, Francesc, QUEROL GINER, Sergi. Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells. _Stem Cell Research & Therapy_. 2021. Vol. 12. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/176988]

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