The effect of pulmonary surfactant on the in vitro activity of Iclaprim against common respiratory bacterial pathogens

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dc.contributor.authorHuang, David B.
dc.contributor.authorDuncan, Leonard R.
dc.contributor.authorFlamm, Robert K.
dc.contributor.authorDryden, Matthew
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorWilcox, Mark H.
dc.contributor.authorTorres Martí, Antoni
dc.contributor.authorFile, Thomas M.
dc.date.accessioned2019-04-12T07:57:52Z
dc.date.available2019-04-12T07:57:52Z
dc.date.issued2018-01
dc.date.updated2019-04-12T07:57:52Z
dc.description.abstractThe in vitro antimicrobial activity of iclaprim, a novel diaminopyrimidine, against common respiratory bacteria remained unchanged in the presence of pulmonary surfactant (Survanta®) at concentrations that greatly antagonized the antimicrobial activity of daptomycin. These results indicate that iclaprim could be a potential treatment for pneumonia caused by susceptible and multidrug resistant bacteria.
dc.format.extent3 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec675127
dc.identifier.issn0732-8893
dc.identifier.urihttps://hdl.handle.net/2445/132145
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.diagmicrobio.2017.09.011
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease, 2018, vol. 90, num. 1, p. 64-66
dc.relation.urihttps://doi.org/10.1016/j.diagmicrobio.2017.09.011
dc.rightscc-by-nc-nd (c) Elsevier B.V., 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es
dc.sourceArticles publicats en revistes (Medicina)
dc.subject.classificationPneumònia
dc.subject.classificationBacteris patògens
dc.subject.classificationEfecte dels medicaments sobre els microorganismes
dc.subject.otherPneumonia
dc.subject.otherPathogenic bacteria
dc.subject.otherEffect of drugs on microorganisms
dc.titleThe effect of pulmonary surfactant on the in vitro activity of Iclaprim against common respiratory bacterial pathogens
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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