Bike peptides: a ride through the membrane

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dc.contributor.authorGarcía Pindado, Júlia
dc.contributor.authorRoyo, Soledad
dc.contributor.authorTeixidó Turà, Meritxell
dc.contributor.authorGiralt Lledó, Ernest
dc.date.accessioned2017-05-08T12:35:56Z
dc.date.available2018-03-16T23:01:20Z
dc.date.issued2017-03-16
dc.date.updated2017-05-08T12:25:05Z
dc.description.abstractSeveral natural peptides have a biaryl or biaryl ether motif in their biologically active structures. A model bicyclic pentapeptide containing a biaryl bridge has been synthesized by solid-phase peptide synthesis combining on-resin Suzuki and Miyaura cross-coupling reactions. Its biological properties in terms of permeability, stability and cytotoxicity have been studied, demon-strating the positive contribution of the biaryl bridge, excellent membrane penetration and serum stabilityeng
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.issn1075-2617
dc.identifier.urihttps://hdl.handle.net/2445/110580
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1002/psc.2993
dc.relation.ispartofJournal of Peptide Science, 2017, vol. 23, num. 4, p. 294-302
dc.relation.urihttp://dx.doi.org/10.1002/psc.2993
dc.rights(c) European Peptide Society and John Wiley & Sons, 2017
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
dc.subject.classificationSíntesi de pèptidscat
dc.subject.classificationProductes naturalscat
dc.subject.classificationSíntesi orgànicacat
dc.subject.otherPeptide synthesiseng
dc.subject.otherNatural productseng
dc.subject.otherOrganic synthesiseng
dc.titleBike peptides: a ride through the membrane
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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