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Article

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Accepted version

Publication date

2017-03-16

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/110580

Bike peptides: a ride through the membrane

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Related resource

http://dx.doi.org/10.1002/psc.2993

Abstract

Several natural peptides have a biaryl or biaryl ether motif in their biologically active structures. A model bicyclic pentapeptide containing a biaryl bridge has been synthesized by solid-phase peptide synthesis combining on-resin Suzuki and Miyaura cross-coupling reactions. Its biological properties in terms of permeability, stability and cytotoxicity have been studied, demon-strating the positive contribution of the biaryl bridge, excellent membrane penetration and serum stability

Subject

Síntesi de pèptids, Productes naturals, Síntesi orgànica

Subject (English)

Peptide synthesis, Natural products, Organic synthesis

Citation

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Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Química Inorgànica i Orgànica)

Citation

GARCÍA PINDADO, Júlia, et al. Bike peptides: a ride through the membrane. Journal of Peptide Science. 2017. Vol. 23, num. 4, pags. 294-302. ISSN 1075-2617. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/110580

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