The brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids

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dc.contributor.authorPaulo de Andrade, Jean
dc.contributor.authorGiordani, R. B.
dc.contributor.authorTorras Claveria, Laura
dc.contributor.authorPigni, Natalia Belén
dc.contributor.authorBerkov, Strahil
dc.contributor.authorFont Bardia, Ma. Mercedes
dc.contributor.authorCalvet Pallàs, Maria Teresa
dc.contributor.authorKonrath, E.
dc.contributor.authorBueno, K.
dc.contributor.authorSachett, L. G.
dc.contributor.authorDutilh, J. H.
dc.contributor.authorBorges, W. D.
dc.contributor.authorViladomat Meya, Francesc
dc.contributor.authorHenriques, A. T.
dc.contributor.authorNair, Jerald J.
dc.contributor.authorZuanazzi, José Ângelo Silveira
dc.contributor.authorBastida Armengol, Jaume
dc.date.accessioned2020-06-02T11:13:06Z
dc.date.available2020-06-02T11:13:06Z
dc.date.issued2016-02
dc.date.updated2020-06-02T11:13:06Z
dc.description.abstractNine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glau-cescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crys-tallographic data for four galanthamine-type com-pounds revealed significant differences in the orientation of theN-methyl group, which are shown to be related to AChE inhibition.
dc.format.extent24 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec656974
dc.identifier.issn1568-7767
dc.identifier.urihttps://hdl.handle.net/2445/163721
dc.language.isoeng
dc.publisherSpringer Science + Business Media
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1007/s11101-015-9411-7
dc.relation.ispartofPhytochemistry Reviews, 2016, vol. 15, num. 1, p. 147-160
dc.relation.urihttps://doi.org/10.1007/s11101-015-9411-7
dc.rights(c) Springer Science + Business Media, 2016
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)
dc.subject.classificationAlcaloides
dc.subject.classificationRadiocristal·lografia
dc.subject.otherAlkaloids
dc.subject.otherX-ray crystallography
dc.titleThe brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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