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Data de publicació

2018-09-13

Llicència de publicació

cc-by (c) Nofrerias Roig, Isaac et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/130115

Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: an improved methodology to determine the Cohesion Index

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Recurs relacionat

https://doi.org/10.1371/journal.pone.0203846

Resum

In this study, we suggest optimizing the methodology to determine the Cohesion Index (Icd) in order to avoid mistaken characterizations due to powder bulk density. For this purpose, five different excipients, with different bulk densities and of different chemical nature, were compressed at different heights. Their compression and their tablet characterization enable establishing a powder weight for compression in accordance with its bulk density. Therefore, the resulting tablet will have a height within a defined range of heights where it has no critical effects on its hardness. Then, the impact of this optimization is shown in a formula development, one of the main SeDeM's applications. A mathematical equation was used to calculate the theoretical amount of excipient to formulate the API according to both methodologies. The compression results demonstrate that the characterization with the NM-Icd is more accurate than the previous one while preserving its simplicity.

Matèries

Excipients, Pólvores (Farmàcia), Comprimits (Medicina)

Matèries (anglès)

Excipients, Powders (Pharmacy), Tablets (Medicine)

Citació

Col·leccions

Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

NOFRERIAS ROIG, Isaac, et al. Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: an improved methodology to determine the Cohesion Index. PLoS One. 2018. Vol. 13, num. 9, pags. e0203846. ISSN 1932-6203. [consulted: 23 of August of 2026]. Available at: https://hdl.handle.net/2445/130115

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