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2024-12-18

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cc-by-nc-nd (c) Domínguez-López, I et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/230106

Microbial phenolic metabolites are associated with better frontal lobe cognition

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https://doi.org/10.26599/FSHW.2023.9250013

Resum

With increasing life expectancy, neurodegenerative diseases have become one of the leading causes of illhealth in the elderly. Preventive strategies include following healthy diets, such as the Mediterranean diet, which is particularly rich in polyphenols, bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDIMED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid, enterodiol glucuronide, enterolactone glucuronide, urolithin B glucuronide, and vanillic acid glucuronide), and cognitive function was evaluated with neuropsychological tests. Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM, and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among individual metabolites, vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multiMPM was associated with better frontal cognitive performance in an older Mediterranean population.

Matèries

Polifenols, Malalties neurodegeneratives

Matèries (anglès)

Polyphenols, Neurodegenerative Diseases

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

Citació

DOMÍNGUEZ LÓPEZ, Inés, et al. Microbial phenolic metabolites are associated with better frontal lobe cognition. Food Science and Human Wellness. 2024. Vol. 13, num. 6, pags. 3266-3272. [consulted: 28 of June of 2026]. Available at: https://hdl.handle.net/2445/230106

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