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2026-05-01

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cc-by-nc-nd (c) López-Vilella, Raquel et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/230404

Combined heart and other organ transplants in Spain: Current review of clinical outcomes. COMBI Study

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Recurs relacionat

https://doi.org/10.1016/j.healun.2026.01.018

Resum

Background: Combined heart transplantation (HTx) with other organs is an established intervention when both organs fail simultaneously or when a noncardiac organ fails after HTx. This study aimed to describe the Spanish experience with this transplant modality and to analyze survival outcomes. Methods: This is a retrospective study based on the Spanish Heart Transplant Registry (1998-2024). Pediatric HTx and patients with previous transplants of other organs were excluded. Patients were classified into isolated HTx (n = 6663), simultaneous combined HTx (n = 147; kidney:60; lung:71; liver:16), and delayed combined HTx (n = 110; kidney:72; hematopoietic stem cells [HSC]:27; liver:10; lung:1). Combined HTx accounted for 3.9% of the total. Results: For simultaneous combined procedures, 30-day survival rates were: HTx+kidney: 84%; HTx+liver: 88%; HTx+lung: 73% (p = 0.034); 5-year survival rates were: 64%, 74%, and 41%, respectively (p = 0.0001). In delayed combined HTx, early mortality was low across all types. Five-year survival rates were: HTx+kidney: 73%; HTx+liver: 67%; HTx+HSC: 59% (p = 0.39). An elective isolated HTx showed better results at 10-year survival than combined HTx, both simultaneous and delayed (p = 0.004). Conclusions: Combined HTx accounts for around 4% of total HTx. Simultaneous heart-liver transplantation provides the best outcomes, while heart-lung transplantation carries the highest risk. Delayed combined HTx shows good early survival.

Matèries

Trasplantament d'òrgans, Avaluació de resultats (Assistència mèdica), Supervivència

Matèries (anglès)

Transplantation of organs, Outcome assessment (Medical care), Survival

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

LÓPEZ-VILELLA, Raquel, et al. Combined heart and other organ transplants in Spain: Current review of clinical outcomes. COMBI Study . Journal of Heart and Lung Transplantation. 2026. Vol. 45, num. 5, pags. 756-767. ISSN 1053-2498. [consulted: 21 of July of 2026]. Available at: https://hdl.handle.net/2445/230404

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