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2020-04-26

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/175633

Morphotropism and 'Quasi-Isostructurality' in the Three High Z′ Concomitant Polymorphs of Efinaconazole

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https://doi.org/10.1021/acs.cgd.0c00586

Abstract

The crystal structures of the three efinaconazole anhydrous forms have been solved by single-crystal X-ray diffraction showing a very rare case of nearly isostructural polymorphism. The analysis of their crystal structures revealed that forms I and III are 'quasi-isostructural' polymorphs and are morphotropically related to form II. The identical conformational and supramolecular environment can explain the concomitant polymorphism phenomenon observed for this important active pharmaceutical ingredient.

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Processos químics, Estructura cristal·lina (Sòlids)

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Chemical processes, Layer structure (Solids)

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Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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PROHENS LÓPEZ, Rafael, BARBAS CAÑERO, Rafael and FONT BARDIA, Ma. Mercedes. Morphotropism and 'Quasi-Isostructurality' in the Three High Z′ Concomitant Polymorphs of Efinaconazole. Crystal Growth & Design. 2020. Vol. 20, num. 7, pags. 4238-4242. ISSN 1528-7483. [consulted: 14 of June of 2026]. Available at: https://hdl.handle.net/2445/175633

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