Oligonucleotide cyclization: The thiol-maleimide reaction revisited

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dc.contributor.authorSánchez-Moya, Albert
dc.contributor.authorPedroso Muller, Enrique
dc.contributor.authorGrandas Sagarra, Anna
dc.date.accessioned2014-02-18T15:19:49Z
dc.date.available2014-12-31T23:02:05Z
dc.date.issued2013
dc.date.updated2014-02-18T11:02:41Z
dc.description.abstractA novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol-derivatized linear precursors. Retro-Diels-Alder conditions deprotecting the maleimide simultaneously promoted cyclization cleanly and in high yield.
dc.format.extent3 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec619951
dc.identifier.issn1359-7345
dc.identifier.pmid23183555
dc.identifier.urihttps://hdl.handle.net/2445/50383
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/ 10.1039/C2CC35357A
dc.relation.ispartofChemical Communications, 2013, vol. 49, p. 309-311
dc.relation.urihttp://dx.doi.org/10.1039/C2CC35357A
dc.rights(c) Sánchez, Albert et al., 2013
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationBioquímica
dc.subject.classificationÀcids nucleics
dc.subject.classificationBacteris
dc.subject.classificationMicrobiologia
dc.subject.classificationCiclització (Química)
dc.subject.otherBiochemistry
dc.subject.otherNucleic acids
dc.subject.otherBacteria
dc.subject.otherMicrobiology
dc.subject.otherRing formation (Chemistry)
dc.titleOligonucleotide cyclization: The thiol-maleimide reaction revisitedeng
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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