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Article

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Accepted version

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2013

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/50383

Oligonucleotide cyclization: The thiol-maleimide reaction revisited

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http://dx.doi.org/10.1039/C2CC35357A

Abstract

A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol-derivatized linear precursors. Retro-Diels-Alder conditions deprotecting the maleimide simultaneously promoted cyclization cleanly and in high yield.

Subject

Bioquímica, Àcids nucleics, Bacteris, Microbiologia, Ciclització (Química)

Subject (English)

Biochemistry, Nucleic acids, Bacteria, Microbiology, Ring formation (Chemistry)

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Articles publicats en revistes (Química Inorgànica i Orgànica)

Citation

SÁNCHEZ-MOYA, Albert, PEDROSO MULLER, Enrique and GRANDAS SAGARRA, Anna. Oligonucleotide cyclization: The thiol-maleimide reaction revisited. Chemical Communications. 2013. Vol. 49, num. 309-311. ISSN 1359-7345. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/50383

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