Files

568522.pdf (251.71 KB)

Document type

Article

Version

Accepted version

Publication date

2009

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/44244

Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs

Journal Title

Authors

Director/Tutor

Additional contribution

Journal ISSN

Volume Title

Abstract

The first dichloroplatinum(II) conjugates of dicarba analogues of octreotide , which is expected to act as a"tumour-targeting device", have been efficiently synthesized following a stepwise solid-phase approach; these compounds emulate the mechanism of cisplatin since they form a 1,2-intrastrand cross-link with two consecutive guanines of an oligonucleotide.

Related resource

http://dx.doi.org/10.1039/B909698A

Subject

ADN, Química bioinorgànica, Quimioteràpia del càncer, Cèl·lules canceroses, Toxicitat dels medicaments

Subject (English)

DNA, Bioinorganic chemistry, Cancer chemotherapy, Cancer cells, Drug toxicity

Citation

Collections

Articles publicats en revistes (Química Inorgànica i Orgànica)

Citation

BARRAGÁN, Flavia, MORENO MARTÍNEZ, Virtudes and MARCHÁN SANCHO, Vicente. Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs. Chemical Communications. 2009. Vol. 4705-4707. ISSN 1359-7345. [consulted: 6 of October of 2026]. Available at: https://hdl.handle.net/2445/44244

Export metadata

JSON - METS

Share record