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Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs

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dc.contributor.authorBarragán, Flavia
dc.contributor.authorMoreno Martínez, Virtudes
dc.contributor.authorMarchán Sancho, Vicente
dc.date.accessioned2013-06-14T07:50:44Z
dc.date.available2013-06-14T07:50:44Z
dc.date.issued2009
dc.date.updated2013-06-14T07:50:44Z
dc.description.abstractThe first dichloroplatinum(II) conjugates of dicarba analogues of octreotide , which is expected to act as a"tumour-targeting device", have been efficiently synthesized following a stepwise solid-phase approach; these compounds emulate the mechanism of cisplatin since they form a 1,2-intrastrand cross-link with two consecutive guanines of an oligonucleotide.
dc.format.extent3 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec568522
dc.identifier.issn1359-7345
dc.identifier.urihttps://hdl.handle.net/2445/44244
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1039/B909698A
dc.relation.ispartofChemical Communications, 2009, p. 4705-4707
dc.relation.urihttp://dx.doi.org/10.1039/B909698A
dc.rights(c) Barragán, Flavia et al., 2009
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationADN
dc.subject.classificationQuímica bioinorgànica
dc.subject.classificationQuimioteràpia del càncer
dc.subject.classificationCèl·lules canceroses
dc.subject.classificationToxicitat dels medicaments
dc.subject.otherDNA
dc.subject.otherBioinorganic chemistry
dc.subject.otherCancer chemotherapy
dc.subject.otherCancer cells
dc.subject.otherDrug toxicity
dc.titleSolid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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