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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/190410
Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
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Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [-2.79 mg/dl (95% CI: -4.25, -1.34) and -5.15 mg/dl (95% CI: -7.38, -2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [-0.09% (95% CI: -0.14, -0.03) and -0.15 % (95% CI: -0.23, -0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: -0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [-1.35 mg/dl (95% CI: -2.12, -0.59), p-value: 0.001]. Keywords: Mediterranean diet; PREDIMED-plus study; cardiovascular health; liquid chromatography; mass spectrometry; plasma carotenoids.
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MARHUENDA-MUÑOZ, María, DOMÍNGUEZ LÓPEZ, Inés, LANGOHR, Klaus, TRESSERRA I RIMBAU, Anna, MARTÍNEZ-GONZÁLEZ, Miguel ángel, SALAS SALVADÓ, Jordi, CORELLA PIQUER, Dolores, ZOMEÑO FAJARDO, María dolores, MARTÍNEZ, J. alfredo, ALONSO GÓMEZ, Ángel m., WÄRNBERG, Julia, VIOQUE, Jesús, ROMAGUERA, Dora, LÓPEZ MIRANDA, José, ESTRUCH RIBA, Ramon, TINAHONES, Francisco j., LAPETRA, José, SERRA MAJEM, Lluís, BUENO CAVANILLAS, Aurora, TUR, Josep antoni, MARTÍN SÁNCHEZ, Vicente, PINTÓ SALA, Xavier, DELGADO RODRIGUEZ, Miguel, MATÍA MARTÍN, Pilar, VIDAL I CORTADA, Josep, VÁZQUEZ, Clotilde, DAIMIEL, Lidia, ROS RAHOLA, Emilio, TOLEDO ATUCHA, Estefanía, FERNÁNDEZ DE LA PUENTE, María, BARRAGÁN, Rocío, FITÓ COLOMER, Montserrat, TOJAL SIERRA, Lucas, GÓMEZ GRACIA, Enrique, ZAZO, Juan manuel, MOREY, Marga, GARCÍA RÍOS, Antonio, CASAS RODRÍGUEZ, Rosa m., GÓMEZ PÉREZ, Ana maría, SANTOS LOZANO, Jose manuel, VÁZQUEZ RUIZ, Zenaida, ATZENI, Alessandro, ASENSIO, Eva m., GILI RIU, M mar, BULLÓN VELA, Vanessa, MORENO RODRIGUEZ, Anai, LECEA JUÁREZ, Oscar, BABIO, Nancy, PEÑAS LOPEZ, Francesca, GÓMEZ MELIS, Guadalupe, LAMUELA RAVENTÓS, Rosa ma.. Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk. _Frontiers In Nutrition_. 2022. Vol. 9, núm. 967967. [consulta: 27 de gener de 2026]. ISSN: 2296-861X. [Disponible a: https://hdl.handle.net/2445/190410]