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Data de publicació

2011

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cc-by-nc-sa (c) Poch, C. et al., 2011
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/45409

Hippocampal Theta-Phase Modulation of Replay Correlates with Configural-Relational Short-Term Memory Performance

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Recurs relacionat

http://doi.org/10.1523/jneurosci.6305-10.2011

Resum

Thereis now growing evidencethatthe hippocampus generatestheta rhythmsthat can phase biasfast neural oscillationsinthe neocortex, allowing coordination of widespread fast oscillatory populations outside limbic areas. A recent magnetoencephalographic study showed that maintenance of configural-relational scene information in a delayed match-to-sample (DMS) task was associated with replay of that information during the delay period. The periodicity of the replay was coordinated by the phase of the ongoing theta rhythm, and the degree of theta coordination during the delay period was positively correlated with DMS performance. Here, we reanalyzed these data to investigate which brain regions were involved in generating the theta oscillations that coordinated the periodic replay of configural- relational information. We used a beamformer algorithm to produce estimates of regional theta rhythms and constructed volumetric images of the phase-locking between the local theta cycle and the instances of replay (in the 13- 80 Hz band). We found that individual differences in DMS performancefor configural-relational associations were relatedtothe degree of phase coupling of instances of cortical reactivations to theta oscillations generated in the right posterior hippocampus and the right inferior frontal gyrus. This demonstrates that the timing of memory reactivations in humans is biased toward hippocampal theta phase

Matèries

Neurologia, Memòria, Circuit neuronal

Matèries (anglès)

Neurology, Memory, Neural circuitry

Citació

Col·leccions

Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

POCH, Claudia, et al. Hippocampal Theta-Phase Modulation of Replay Correlates with Configural-Relational Short-Term Memory Performance. Journal of Neuroscience. 2011. Vol. 31, num. 19, pags. 7038-7042. ISSN 0270-6474. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/45409

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