Light-Activated Pharmacological Tools for Exploring the Cholinergic System

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dc.contributor.authorColleoni, Alessio
dc.contributor.authorGalli, Giulia
dc.contributor.authorDallanoce, Clelia
dc.contributor.authorAmici, Marco de
dc.contributor.authorGorostiza Langa, Pablo Ignacio
dc.contributor.authorMatera, Carlo
dc.date.accessioned2025-05-30T06:42:31Z
dc.date.available2025-05-30T06:42:31Z
dc.date.issued2025-03-23
dc.date.updated2025-05-21T12:48:04Z
dc.description.abstractCholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to overcome the limitations of traditional drugs using photocleavable or photoswitchable ligands and spatiotemporal patterns of illumination. Spanning from muscarinic and nicotinic modulators to cholinesterase inhibitors, this review explores the development and application of light-activated compounds as tools for unraveling the role of cholinergic signaling in both physiological and pathological contexts, while also paving the way for innovative phototherapeutic approaches.
dc.format.extent24 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idimarina6729235
dc.identifier.issn1098-1128
dc.identifier.pmid40123150
dc.identifier.urihttps://hdl.handle.net/2445/221269
dc.language.isoeng
dc.publisherWiley
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1002/med.22108
dc.relation.ispartofMedicinal Research Reviews, 2025
dc.relation.urihttps://doi.org/10.1002/med.22108
dc.rightscc-by (c) Colleoni, Alessio et al., 2025
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
dc.subject.classificationFotofarmacologia
dc.subject.classificationBioquímica
dc.subject.classificationReceptors colinèrgics
dc.subject.otherPhotopharmacology
dc.subject.otherBiochemistry
dc.subject.otherAcetylcholine receptors
dc.titleLight-Activated Pharmacological Tools for Exploring the Cholinergic System
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))