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2010-05-19

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/179784

Modified siRNAs for the study of the PAZ domain

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Abstract

Chemical modifications aimed at stabilizing the interaction between the 3'-end of siRNAs and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such modifications contribute positively to the stability of siRNAs in human serum.

Related resource

https://doi.org/10.1039/C003221B

Subject

RNA, Fixació de proteïnes, Modificació química de les proteïnes

Subject (English)

RNA, Protein binding, Chemical modification of proteins

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Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citation

SOMOZA, Álvaro, TERRAZAS MARTÍNEZ, Montserrat and ERITJA I CASADELLÀ, Ramon. Modified siRNAs for the study of the PAZ domain. Chemical Communications. 2010. Vol. 46, num. 4270-4272. ISSN 1359-7345. [consulted: 12 of October of 2026]. Available at: https://hdl.handle.net/2445/179784

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