PRL-3 overexpression in epithelial cells is induced by surrounding stromal fibroblasts

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dc.contributor.authorGarcia i Molleví, David
dc.contributor.authorAytés Meneses, Álvaro
dc.contributor.authorBerdiel Acer, Mireia
dc.contributor.authorPadullés Mosella, Laura
dc.contributor.authorMartínez Iniesta, María
dc.contributor.authorSanjuan, Xavier
dc.contributor.authorSalazar Soler, Ramón
dc.contributor.authorVillanueva Garatachea, Alberto
dc.date.accessioned2018-11-09T08:57:41Z
dc.date.available2018-11-09T08:57:41Z
dc.date.issued2009-07-08
dc.date.updated2018-11-09T08:57:41Z
dc.description.abstractWe isolate and culture carcinoma-associated fibroblasts (CAFs) from primary tumour (CAFpt), CAFs from corresponding synchronous liver metastasis (CAFlm) as well as normal colonic fibroblasts (NCF) from the same patient. From these cultures, conditioned media (CM) was obtained. Culture of a wide panel of colorectal and pancreatic cell lines in CM from CAFlm resulted in overexpression of mRNA PRL-3 and higher overexpression in CAFs than in non-activated fibroblasts. Moreover PRL-3 mRNA expression correlates with expression of alpha-SMA and deposition of collagen fibrils in the stroma. We demonstrate that products secreted by CAFs trigger PRL-3 overexpression in cancer cells. Identification of these factors may contribute to new stroma-targeted therapies for desmoplastic tumours
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec647792
dc.identifier.issn1476-4598
dc.identifier.pmid19586538
dc.identifier.urihttps://hdl.handle.net/2445/125936
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1186/1476-4598-8-46
dc.relation.ispartofMolecular Cancer, 2009, vol. 8, p. 46
dc.relation.urihttps://doi.org/10.1186/1476-4598-8-46
dc.rightscc-by (c) Garcia i Molleví, David et al., 2009
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Ciències Clíniques)
dc.subject.classificationCàncer
dc.subject.classificationFibroblasts
dc.subject.classificationMetàstasi
dc.subject.otherCancer
dc.subject.otherFibroblasts
dc.subject.otherMetastasis
dc.titlePRL-3 overexpression in epithelial cells is induced by surrounding stromal fibroblasts
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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