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2022-01-18

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cc-by (c) Fortea, Lydia et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183196

Focusing on Comorbidity A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders

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https://doi.org/10.3389/fpsyt.2021.807839

Resum

Background: In mental health, comorbidities are the norm rather than the exception. However, current meta-analytic methods for summarizing the neural correlates of mental disorders do not consider comorbidities, reducing them to a source of noise and bias rather than benefitting from their valuable information. Objectives: We describe and validate a novel neuroimaging meta-analytic approach that focuses on comorbidities. In addition, we present the protocol for a meta-analysis of all major mental disorders and their comorbidities. Methods: The novel approach consists of a modification of Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) in which the linear models have no intercept. As in previous SDM meta-analyses, the dependent variable is the brain anatomical difference between patients and controls in a voxel. However, there is no primary disorder, and the independent variables are the percentages of patients with each disorder and each pair of potentially comorbid disorders. We use simulations to validate and provide an example of this novel approach, which correctly disentangled the abnormalities associated with each disorder and comorbidity. We then describe a protocol for conducting the new meta-analysis of all major mental disorders and their comorbidities. Specifically, we will include all voxel-based morphometry (VBM) studies of mental disorders for which a meta-analysis has already been published, including at least 10 studies. We will use the novel approach to analyze all included studies in two separate single linear models, one for children/adolescents and one for adults. Discussion: The novel approach is a valid method to focus on comorbidities. The meta-analysis will yield a comprehensive atlas of the neuroanatomy of all major mental disorders and their comorbidities, which we hope might help develop potential diagnostic and therapeutic tools.

Matèries

Malalties mentals, Comorbiditat, Diagnòstic, Imatges per ressonància magnètica

Matèries (anglès)

Mental illness, Comorbidity, Diagnosis, Magnetic resonance imaging

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

FORTEA, Lydia, ALBAJES EIZAGIRRE, Anton, YAO, Yuan wei, SOLER, Edu, VERDOLINI, Norma, HAUSON, Alexander o., FORTEA, Adriana, MADERO GÓMEZ, Santiago, SOLANES, Aleix, WOLLMAN, Scott c., SERRA BLASCO, María, WISE, Toby, LUKITO, Steve, PICÓ PÉREZ, Maria, CARLISI, Christina, ZHANG, Jin tao, PAN, Pinglei, FARRÉ COLOMÉS, Álvar, ARNONE, Danilo, KEMPTON, Matthew j., SORIANO MAS, Carles, RUBIA, Katya, NORMAN, Luke, FUSAR-POLI, Paolo, MATAIX-COLS, David, VALENTÍ RIBAS, Marc, VIA VIRGILI, Esther, CARDONER, N. (narcís), SOLMI, Marco, SHIN, Jae i., VIETA I PASCUAL, Eduard, RADUA, Joaquim. Focusing on Comorbidity A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders. _Frontiers In Psychiatry_. 2022. Vol. 12, núm. 807839. [consulta: 20 de gener de 2026]. ISSN: 1664-0640. [Disponible a: https://hdl.handle.net/2445/183196]

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