El CRAI romandrà tancat del 24 de desembre de 2025 al 6 de gener de 2026. La validació de documents es reprendrà a partir del 7 de gener de 2026.
El CRAI permanecerá cerrado del 24 de diciembre de 2025 al 6 de enero de 2026. La validación de documentos se reanudará a partir del 7 de enero de 2026.
From 2025-12-24 to 2026-01-06, the CRAI remain closed and the documents will be validated from 2026-01-07.
 
Miniatura

Fitxers

898380.pdf (7.22 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2025-08-01

Llicència de publicació

cc-by-nc (c) Carretero-Fernández, María et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222844

Autophagy and oxidative stress in solid tumors: mechanisms and therapeutic opportunities

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.critrevonc.2025.104820

Resum

Cancer remains a leading cause of mortality worldwide, with solid tumors representing most cases. Autophagy and oxidative stress are two interconnected cellular mechanisms that influence tumor initiation, therapeutic response and disease progression. Autophagy plays a context-dependent role, functioning as a tumor suppressor by eliminating damaged organelles in early stages, while later supporting tumor survival under metabolic and therapeutic stress. Similarly, oxidative stress, characterized by an imbalance in reactive oxygen species (ROS), can drive tumorigenesis by promoting genomic instability and resistance to therapy but can also induce apoptosis in cancer cells. The crosstalk between autophagy and oxidative stress plays a pivotal role in shaping the tumor microenvironment, affecting immune evasion, drug resistance, and metabolic adaptation. Targeting these processes through pharmacological modulation presents both challenges and opportunities in cancer therapy. While autophagy inhibition can enhance chemotherapy efficacy by preventing tumor cell survival mechanisms, excessive oxidative stress induction may lead to cellular damage and systemic toxicity. This review explores the complex interplay between autophagy and oxidative stress in solid tumors, emphasizing their implications for cancer progression and treatment strategies. By understanding these mechanisms, novel therapeutic approaches, including combination therapies and precision medicine strategies, may be developed to improve patient outcomes.

Matèries

Tumors, Estrès oxidatiu, Autofàgia

Matèries (anglès)

Tumors, Oxidative stress, Autophagy

Citació

Col·leccions

Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

CARRETERO-FERNÁNDEZ, María, CABRERA-SERRANO, Antonio josé, SÁNCHEZ-MALDONADO, José manuel, RUIZ-DURÁN, Lucía, JIMÉNEZ-ROMERA, Francisco, GARCÍA VERDEJO, Francisco josé, GONZÁLEZ-OLMEDO, Carmen, CARDÚS, Aina, DÍAZ-BELTRÁN, Letícia, GUTIÉRREZ-BAUTISTA, Juan francisco, BENAVENTE, Yolanda, GÁLVEZ-MONTOSA, Fernando, LÓPEZ-LÓPEZ, José antonio, GARCÍA-MARTÍN, Paloma, PÉREZ, Eva maría, RODRÍGUEZ-SEVILLA, Juan josé, CASABONNE, Delphine, SÁNCHEZ ROVIRA, Pedro, REYES-ZURITA, Fernando j., SAINZ, Juan. Autophagy and oxidative stress in solid tumors: mechanisms and therapeutic opportunities. _Critical Reviews in Oncology Hematology_. 2025. Vol. 212. [consulta: 1 de gener de 2026]. ISSN: 1040-8428. [Disponible a: https://hdl.handle.net/2445/222844]

Exportar metadades

JSON - METS

Compartir registre