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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/194018
Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
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Abstract
Amyloid aggregation is linked to a number of human disorders that range from non-neurological illnesses such as type 2 diabetes to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The formation of insoluble protein aggregates with amyloid conformation inside bacteria, namely, in bacterial inclusion bodies, offers the possibility to use bacteria as simple models to study amyloid aggregation processes and potential effects of both anti-amyloid drugs and/or pro-aggregative compounds. This chapter describes fast, simple, inexpensive, highly reproducible, and tunable in vitro and in cellulo methods that use bacterial inclusion bodies as preliminary screening tools for anti-amyloid drugs. Keywords: Amyloid aggregation; Bacterial inclusion body; Conformational disease; Drug screening.
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CABALLERO HERNÁNDEZ, Ana Belén, et al. Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies. Methods in Molecular Biology. 2022. Vol. 2538, num. 165-188. ISSN 1940-6029. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/194018