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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/178957
Direct and enantioselective aldol reactions catalyzed by chiral nickel(II) complexes
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A direct and asymmetric aldol reaction of N-acylthiazinanethiones with aromatic aldehydes catalyzed by chiralnickel(II) complexes is reported. The reaction gives thecorresponding O-TIPS-protected anti-aldol adducts in highyields and with remarkable stereocontrol and atom economy.Furthermore, the straightforward removal of the achiralscaffold provides enantiomerically pure intermediates ofsynthetic interest, which involve precursors for anti-a-amino-b-hydroxy anda,b-dihydroxy carboxylic derivatives. Theoret-ical calculations explain the observed high stereocontrol.
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KENNINGTON, Stuart C. D., et al. Direct and enantioselective aldol reactions catalyzed by chiral nickel(II) complexes. Angewandte Chemie-International Edition. 2021. Vol. 60, num. 28, pags. 15307-15312. ISSN 1433-7851. [consulted: 6 of June of 2026]. Available at: https://hdl.handle.net/2445/178957