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2023-08-24

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cc-by (c) Villanueva, Bernat et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/204935

Aflibercept for Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia: A Case Report.

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https://doi.org/10.3390/medicina59091533

Abstract

Herein, we present the first described hereditary hemorrhagic telangiectasia (HHT) pa- tient treated with aflibercept for severe GI involvement after tachyphylaxis to bevacizumab, with promising results. HHT is a rare genetic disease characterized by systemic vascular malformations. Gastrointestinal telangiectasia is one of the major involvements that can produce chronic severe iron-deficiency anemia. Nowadays, support treatment with iron replacement therapy, red blood cell transfusions, and antiangiogenic drugs—mainly bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF)—are the main therapeutic options for this complication. The evidence of alternative drugs in patients with failure to this approach, such as tachyphylaxis to bevacizumab, is scarce. Aflibercept is a VEGF inhibitor with antiangiogenic properties approved for the treatment of different types of cancer and ocular neovascularization diseases.

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Angiogènesi, Vasos sanguinis, Hemorràgia

Subject (English)

Neovascularization, Blood vessels, Hemorrhage

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

VILLANUEVA, Bernat, et al. Aflibercept for Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia: A Case Report. Medicina (Kaunas). 2023. Vol. 59, num. 9. ISSN 1010-660X. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/204935

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