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Published version

Publication date

2024-03-04

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cc-by-nc (c) Lozano Baró, Eloy et al., 2024
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/224699

Drugs from Drugs: New Chemical Insights into a Mature Concept

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https://doi.org/10.1016/j.drudis.2024.104212

Abstract

Developing new drugs from marketed ones is a well-established and successful approach in drug discovery. We offer a unified view of this field, focusing on the new chemical aspects of the involved approaches: (a) chemical transformation of the original drugs (late-stage modifications, molecular editing), (b) prodrug strategies, and (c) repurposing as a tool to develop new hits/leads. Special focus is placed on the molecular structure of the drugs and their synthetic feasibility. The combination of experimental advances and new computational approaches, including artificial intelligence methods, paves the way for the evolution of the drugs from drugs concept.

Subject

Farmacologia, Desenvolupament de medicaments

Subject (English)

Pharmacology, Drug development

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Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

Citation

LOZANO BARÓ, Eloy, et al. Drugs from Drugs: New Chemical Insights into a Mature Concept. Drug Discovery Today. 2024. Vol. 29, num. 12. ISSN 1359-6446. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/224699

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