Drugs from Drugs: New Chemical Insights into a Mature Concept

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dc.contributor.authorLozano Baró, Eloy
dc.contributor.authorCatti, Federica
dc.contributor.authorEstarellas, Carolina
dc.contributor.authorGhashghaei, Ouldouz
dc.contributor.authorLavilla Grífols, Rodolfo
dc.date.accessioned2025-12-04T18:38:32Z
dc.date.available2025-12-04T18:38:32Z
dc.date.issued2024-03-04
dc.date.updated2025-12-04T18:38:32Z
dc.description.abstractDeveloping new drugs from marketed ones is a well-established and successful approach in drug discovery. We offer a unified view of this field, focusing on the new chemical aspects of the involved approaches: (a) chemical transformation of the original drugs (late-stage modifications, molecular editing), (b) prodrug strategies, and (c) repurposing as a tool to develop new hits/leads. Special focus is placed on the molecular structure of the drugs and their synthetic feasibility. The combination of experimental advances and new computational approaches, including artificial intelligence methods, paves the way for the evolution of the drugs from drugs concept.
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec753357
dc.identifier.issn1359-6446
dc.identifier.pmid39442750
dc.identifier.urihttps://hdl.handle.net/2445/224699
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.drudis.2024.104212
dc.relation.ispartofDrug Discovery Today, 2024, vol. 29, num.12
dc.relation.urihttps://doi.org/10.1016/j.drudis.2024.104212
dc.rightscc-by-nc (c) Lozano Baró, Eloy et al., 2024
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.classificationFarmacologia
dc.subject.classificationDesenvolupament de medicaments
dc.subject.otherPharmacology
dc.subject.otherDrug development
dc.titleDrugs from Drugs: New Chemical Insights into a Mature Concept
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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