Miniatura

Fitxers

902603.pdf (1.09 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2025-08-01

Llicència de publicació

cc-by (c) Romano, Antonio et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/223849

Updating the classification and routine diagnosis of NSAID hypersensitivity reactions: A WAO Statement

Títol de la revista

Autors

ISSN de la revista

Títol del volum

Resum

Hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) have been classified as immediate (or acute) and delayed. Immediate reactions can be further classified into 4 clinical types: NSAID-exacerbated respiratory disease (N-ERD), NSAID-exacerbated cutaneous disease (NECD), NSAID-induced urticaria/angioedema (NIUA), and single NSAID-induced urticaria/angioedema/anaphylaxis (SNIUAA). Specifically, the NIUA type references reactions to ≥2 NSAIDs belonging to different chemical groups, involving urticaria and/or angioedema in patients with no underlying chronic spontaneous urticaria. However, there are patients meeting cross-reactive criteria for NIUA phenotype who report reactions that involve 2 organ systems (eg, cutaneous and respiratory; cutaneous and gastrointestinal) and have been termed “blended”. In pediatrics, this type of reaction is recognized and has been termed NSAID-induced urticaria/angioedema/anaphylaxis (NIUAA), an acronym we suggest be extended now to adults. There are small subgroups of N-ERD patients who also report skin symptoms and, alternatively, NECD patients who report respiratory symptoms. These 2 subgroups could be diagnosed as having mixed N-ERD and mixed NECD, respectively. In fact, they are patients suffering from N-ERD or NECD who have had reactions consistent with anaphylaxis. In the current classifications of NSAID hypersensitivity, the reactions in which NSAIDs act as aggravating factors or cofactors in subjects with sensitization to foods are not included. Recently, this type of reactions has been defined as NSAID-exacerbated food allergy (NEFA) and NSAID-induced food allergy (NIFA), respectively. This Statement of the World Allergy Organization (WAO) aims to update both the classification of hypersensitivity reactions to NSAIDs and their diagnosis, addressing the novel issues.

Descripció

Matèries

Al·lèrgia als medicaments, Urticària

Matèries (anglès)

Drug allergy, Urticaria

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

ROMANO, Antonio, VALLUZZI, Rocco l., ALVAREZ CUESTA, Emilio, ANSOTEGUI, Ignacio, ASERO, Riccardo, BARBAUD, Annick, BARTRA TOMÀS, Joan, BAVBEK, Sevim, CAHILLI, Katherine n., DEMOLY, Pascal, DOÑA, Inmaculada, GUZMÁN MELÉNDEZ, Maria a., KIDON, Mona, LI, Lily, MADRIGAL BURGALETA, Ricardo, MAKOWSKA, Joanna, PARK, Hae-sim, PICADO VALLÉS, César, SANAK, Marek, TANIGUCHI, Masami, WHITE, Andrew a., ATANASKOVIC-MARKOVIC, Marina, ATTANASI, Marina, AUN, Marcelo vivolo, BERGES GIMENO, Maria pilar, BERNAL RUBIO, Lorena, BROCKOW, Knut, BUSTAMANTE, Lucrecia, CAFFARELLI, Carlo, CHANG, Yoon seok, CHIKHLADZE, Manana, ENSINA, Luis felipe, FERNANDES, Brayan n., GARVEY, Lene heise, GIAVINA BIANCHI, Pedro, GÓMES, Eva, KUYUCU, Semanur, LABELLA, Marina, MAYORGA, Cristobalina, MORI, Francesca, PAGANI, Mauro, PALMA PINO, Valeria, PARISI, Claudio a. s., PHILLIPS, Elizabeth, POWELL, Elizabeth, RAMIEN, Michelle, SAVIC, Louise, SOLANO SOLARES, Emilio, TANNO, Luciana kase, VÁZQUEZ REVUELTA, Paula, WATTS, Timothy, YAMAGUCHI, Masao. Updating the classification and routine diagnosis of NSAID hypersensitivity reactions: A WAO Statement. _World Allergy Organization Journal_. 2025. Vol. 18, núm. 8. [consulta: 24 de novembre de 2025]. [Disponible a: https://hdl.handle.net/2445/223849]

Exportar metadades

JSON - METS

Compartir registre