Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/216098
The role of opioid transmission in music‐induced pleasure
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Studies conducted in rodents indicate a crucial role of the opioid circuit in mediating objective hedonic reactions to primary rewards. However, it remains unclear whether opioid transmission is also essential to experience pleasure with more abstract rewards, such as music. We addressed this question using a double-blind within-subject pharmacological design in which opioid levels were up- and downregulated by administering an opioid agonist (oxycodone) and antagonist (naltrexone), respectively, before healthy participants (n = 21) listened to music. Participants also performed a monetary incentive delay (MID) task to control for the effectiveness of the treatment and the specificity of the effects. Our results revealed that the pharmacological intervention did not modulate subjective reports of pleasure, nor the occurrence of chills. On the contrary, psychophysiological (objective) measures of emotional arousal, such as skin conductance responses (SCRs), were bidirectionally modulated in both the music and MID tasks. This modulation specifically occurred during reward consumption, with greater pleasure related SCR following oxycodone than naltrexone. These findings indicate that opioid transmission does not modulate subjective evaluations but rather affects objective reward-related psychophysiological responses. These findings raise new caveats about the role of the opioidergic system in the modulation of pleasure for more abstract or cognitive forms of rewarding experiences, such as music.
Citació
Citació
MAS-HERRERO, Ernest, FERRERI, Laura, CARDONA, Gemma, ZATORRE, Robert j., PLA-JUNCÀ, Francesc, ANTONIJOAN ARBÓS, Rosa ma. (rosa maría), RIBA, Jordi, VALLE, Marta, RODRÍGUEZ FORNELLS, Antoni. The role of opioid transmission in music‐induced pleasure. _Annals of the New York Academy of Sciences_. 2023. Vol. 1520, núm. 1, pàgs. 105-114. [consulta: 21 de gener de 2026]. ISSN: 0077-8923. [Disponible a: https://hdl.handle.net/2445/216098]