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2019-09-16

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cc-by (c) Roca Millan, Elisabet et al., 2019
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/158757

The Application of Statins in the Regeneration of Bone Defects. Systematic Review and Meta-Analysis

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https://doi.org/10.3390/ma12182992

Abstract

This systematic review aims to analyze the effect of the local application of statins in the regeneration of non-periodontal bone defects. A systematic study was conducted with the Pubmed/Medline, Embase, Cochrane Library and Scielo databases for in vivo animal studies published up to and including February 2019. Fifteen articles were included in the analysis. The local application of the drug increased the percentage of new bone formation, bone density, bone healing, bone morphogenetic protein 2, vascular endothelial growth factor, progenitor endothelial cells and osteocalcin. Meta-analyses showed a statistically significant increase in the percentage of new bone formation when animals were treated with local statins, in contrast to the no introduction of filling material or the introduction of polylactic acid, both in an early (4-6 weeks) and in a late period (12 weeks) (mean difference 39.5%, 95% confidence interval: 22.2-56.9, p <0.001; and mean difference 43.3%, 95% confidence interval: 33.6-52.9, p < 0.001, respectively). Basing on the animal model, the local application of statins promotes the healing of critical bone size defects due to its apparent osteogenic and angiogenic effects. However, given the few studies and their heterogenicity, the results should be taken cautiously, and further pilot studies are necessary, with radiological and histological evaluations to translate these results to humans and establish statins' effect.

Subject

Creixement dels ossos, Farmacologia, Medicina regenerativa

Subject (English)

Bones growth, Pharmacology, Regenerative medicine

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Articles publicats en revistes (Odontoestomatologia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

ROCA MILLAN, Elisabet, et al. The Application of Statins in the Regeneration of Bone Defects. Systematic Review and Meta-Analysis. Materials. 2019. Vol. 12, num. 18, pags. 2992. ISSN 1996-1944. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/158757

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