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2025-03-28

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cc by (c) Prospective Lynch Syndrome Database, 2025
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222101

Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database

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https://doi.org/10.1093/bjs/znaf061

Abstract

This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.

Subject

Cirurgia colorectal, Càncer colorectal

Subject (English)

Colorectal cancer, Colorectal surgery

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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Prospective Lynch Syndrome Database, et al. Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database. British journal of surgery. 2025. Vol. 112, num. 4. ISSN 1365-2168. [consulted: 13 of June of 2026]. Available at: https://hdl.handle.net/2445/222101

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