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2022-11-17

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cc-by (c) Solanes, A. et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/220204

Combining MRI and clinical data to detect high relapse risk after the first episode of psychosis

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Recurs relacionat

https://doi.org/10.1038/s41537-022-00309-w

Resum

Detecting patients at high relapse risk after the first episode of psychosis (HRR-FEP) could help the clinician adjust the preventive treatment. To develop a tool to detect patients at HRR using their baseline clinical and structural MRI, we followed 227 patients with FEP for 18-24 months and applied MRIPredict. We previously optimized the MRI-based machine-learning parameters (combining unmodulated and modulated gray and white matter and using voxel-based ensemble) in two independent datasets. Patients estimated to be at HRR-FEP showed a substantially increased risk of relapse (hazard ratio = 4.58, P < 0.05). Accuracy was poorer when we only used clinical or MRI data. We thus show the potential of combining clinical and MRI data to detect which individuals are more likely to relapse, who may benefit from increased frequency of visits, and which are unlikely, who may be currently receiving unnecessary prophylactic treatments. We also provide an updated version of the MRIPredict software.

Matèries

Factors de risc en les malalties, Psicosi, Ressonància magnètica

Matèries (anglès)

Risk factors in diseases, Psychoses, Magnetic resonance

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Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

SOLANES, Aleix, et al. Combining MRI and clinical data to detect high relapse risk after the first episode of psychosis. Schizophrenia. 2022. Vol. 8. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/220204

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