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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/173082
Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study
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Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4-7.3) years, 97 CRC events were considered. A significant linear association was observed between each 1-point increment in the WCRF/AICR score (score range from 0 to 7) and CRC risk (HR (95% CI) = 0.79 (0.63-0.99)). Similarly, each 1-point increment in the LRL score (score range from 0 to 5) was associated with a 22% reduction in CRC risk (0.78 (0.64-0.96)). Adhering to emergent lifestyle scores might substantially reduce CRC incidence in elderly individuals. Further longitudinal studies, which take different lifestyle indexes into account, are warranted in the future.
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BARRUBÉS, Laura, BABIO, Nancy, HERNÁNDEZ ALONSO, Pablo, TOLEDO ATUCHA, Estefanía, RAMÍREZ SABIO, Judith b., ESTRUCH RIBA, Ramon, ROS RAHOLA, Emilio, FITÓ COLOMER, Montserrat, ALONSO GÓMEZ, Ángel m., FIOL SALA, Miguel, LAPETRA, José, SERRA MAJEM, Lluís, PINTÓ SALA, Xavier, RUIZ CANELA, Miguel, CORELLA PIQUER, Dolores, CASTAÑER, Olga, MACÍAS GONZÁLEZ, Manuel, SALAS SALVADÓ, Jordi. Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study. _Journal of Clinical Medicine_. 2020. Vol. 9, núm. 4. [consulta: 8 de abril de 2026]. [Disponible a: https://hdl.handle.net/2445/173082]