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nutrients-13-03132.pdf (319.93 KB)

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2021-09-08

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cc by (c) Aglago, Elom K. et al, 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/180637

Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

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https://doi.org/10.3390/nu13093132

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Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: Nε-carboxy-methyllysine (CML), Nε-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89-1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.

Matèries

Càncer colorectal, Avaluació de l'estat nutricional

Matèries (anglès)

Colorectal cancer, Nutritional status measurement

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Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

AGLAGO, Elom k., MAYÉN, Ana lucia, KNAZE, Viktoria, FREISLING, Heinz, FEDIRKO, Veronika, HUGHES, David j., JIAO, Li, ERIKSEN, Anne kirstine, TJØNNELAND, Anne, BOUTRON-RUAULT, Marie-christine, ROTHWELL, Joseph a., SEVERI, Gianluca, KAAKS, Rudolf, KATZKE, Verena, SCHULZE, Matthias b., BIRUKOV, Anna, PALLI, Domenico, SIERI, Sabina, SANTUCCI DE MAGISTRIS, Maria, TUMINO, Rosario, RICCERI, Fulvio, BUENO DE MESQUITA, H. bas, DERKSEN, Jeroen w. g., SKEIE, Guri, GRAM, Inger t., SANDANGER, Torkjel m., QUIRÓS, José ramón, LUJÁN BARROSO, Leila, SÁNCHEZ, Maria-jose, AMIANO, Pilar, CHIRLAQUE, María dolores, GURREA, Aurelio barricarte, JOHANSSON, Ingegerd, MANJER, Jonas, PÉREZ CORNAGO, Aurora, WEIDERPASS, Elisabete, GUNTER, Marc j., HEATH, Alicia k., SCHALKWIJK, Casper g., JENAB, Mazda. Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. _Nutrients_. 2021. Vol. 13, núm. 9, pàgs. 3132. [consulta: 16 de gener de 2026]. ISSN: 2072-6643. [Disponible a: https://hdl.handle.net/2445/180637]

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