A direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars

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dc.contributor.authorTerrazas Martínez, Montserrat
dc.contributor.authorAviñó Andrés, Anna
dc.contributor.authorSiddiqui, Maqbool A.
dc.contributor.authorMarquez, Victor E.
dc.contributor.authorEritja i Casadellà, Ramon
dc.date.accessioned2021-08-31T10:31:28Z
dc.date.available2021-08-31T10:31:28Z
dc.date.issued2011-05-09
dc.date.updated2021-08-31T10:31:28Z
dc.description.abstractAn efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec713432
dc.identifier.issn1523-7060
dc.identifier.urihttps://hdl.handle.net/2445/179783
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1021/ol200909j
dc.relation.ispartofOrganic Letters, 2011, vol. 13, num. 11, p. 2888-2891
dc.relation.urihttps://doi.org/10.1021/ol200909j
dc.rights(c) American Chemical Society , 2011
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationRNA
dc.subject.classificationNucleòsids
dc.subject.classificationEstructura molecular
dc.subject.otherRNA
dc.subject.otherNucleosides
dc.subject.otherMolecular structure
dc.titleA direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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