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Article

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Accepted version

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2011-05-09

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/179783

A direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars

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https://doi.org/10.1021/ol200909j

Abstract

An efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA.

Subject

RNA, Nucleòsids, Estructura molecular

Subject (English)

RNA, Nucleosides, Molecular structure

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Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citation

TERRAZAS MARTÍNEZ, Montserrat, et al. A direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars. Organic Letters. 2011. Vol. 13, num. 11, pags. 2888-2891. ISSN 1523-7060. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/179783

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