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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/201129
Fracture risk after deprescription of bisphosphonates: Application of real-world data in primary care
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Purpose: To compare the effect of discontinuing bisphosphonate treatment on fracture risk in postmenopausal women at high versus low risk of fracture.Design: Retrospective, longitudinal and population-based cohort study.Setting: Barcelona City Primary Care. Catalan Health Institute. Participants: All women attended by primary care teams who in January 2014 had received bisphosphonate treatment for at least five years were included and followed for another five years.Intervention: Patients were classified according to their risk of new fractures, defined as those who had a history of osteoporotic fracture and/or who received treatment with an aromatase inhibitor, and the continuity or deprescription of the bisphosphonate treatment was analyzed over fiver year follow-up.Main measurements: The cumulative incidence of fractures and the incidence density were calculated and analyzed using logistic regression and Cox models.Results: We included 3680 women. There were no significant differences in fracture risk in high-risk women who discontinued versus continued bisphosphonate treatment (hazard ratio [HR] 1.17, 95% confidence interval [CI] 0.87--1.58 for total osteoporotic fractures). However, discontinuers at low risk had a lower incidence of fracture than continuers. This difference was significant for vertebral fractures (HR 0.64, 95% CI 0.47-0.88) and total fractures (HR 0.77, 95% CI 0.64-0.92).
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TRONCOSO MARIÑO, Amelia, et al. Fracture risk after deprescription of bisphosphonates: Application of real-world data in primary care. Atención Primaria. 2023. Vol. 55, num. 7. ISSN 1578-1275. [consulted: 14 of June of 2026]. Available at: https://hdl.handle.net/2445/201129