A role for caspase-8 and TRAIL-R2/DR5 in ER-stress induced apoptosis

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dc.contributor.authorMuñoz Pinedo, Cristina
dc.contributor.authorLópez Rivas, Abelardo
dc.date.accessioned2017-11-27T15:13:58Z
dc.date.available2018-04-06T22:01:23Z
dc.date.issued2017-10-06
dc.description.abstractGlab and colleagues examine in a recent paper apoptosis induced by some driverss of endoplasmic reticulum (ER) stress. They conclude that in contrast to a previously published report2 , DR5/TRAIL-R2 and caspase-8 are universally dispensable in ER stress-induced apoptosis. We argue here that their own data and other published reports indicate that in many models, DR5 and/or caspase-8 are essential players in apoptosis mediated by the unfolded protein response (UPR), upon chronic ER stress.ca
dc.format.extent5 p.
dc.format.extent5 p.
dc.format.mimetypeapplication/pdf
dc.identifier.issn1476-5403
dc.identifier.pmid28984868
dc.identifier.urihttps://hdl.handle.net/2445/118182
dc.language.isoengca
dc.publisherNature Publishing Group
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1038/cdd.2017.155
dc.relation.ispartofCell Death & Differentiation, 2017, num. 1 October
dc.relation.urihttp://dx.doi.org/10.1038/cdd.2017.155
dc.rights(c) Cell Death & Differentiation, 2017
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationProteïnes
dc.subject.classificationApoptosi
dc.subject.otherProteins
dc.subject.otherApoptosis
dc.titleA role for caspase-8 and TRAIL-R2/DR5 in ER-stress induced apoptosisca
dc.typeinfo:eu-repo/semantics/otherca
dc.typeinfo:eu-repo/semantics/acceptedVersion

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