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2022-01-11

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/212660

Neural predictors of cognitive-behavior therapy outcome in anxiety-related disorders: A meta-analysis of task-based fMRI studies

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https://doi.org/10.1017/S0033291721005444

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Background: Cognitive-behavior therapy (CBT) is a well-established first-line intervention for anxiety-related disorders, including specific phobia, social anxiety disorder, panic disorder/agoraphobia, generalized anxiety disorder, obsessive-compulsive disorder, and posttraumatic stress disorder. Several neural predictors of CBT outcome for anxiety-related disorders have been proposed, but previous results are inconsistent. Methods: We conducted a systematic review and meta-analysis of task-based functional magnetic resonance imaging (fMRI) studies investigating whole-brain predictors of CBT outcome in anxiety-related disorders (17 studies, n=442). Results: Across different tasks, we observed that brain response in a network of regions involved in salience and interoception processing, encompassing frontoinsular (the right inferior frontal gyrus-anterior insular cortex) and fronto-limbic (the dorsomedial prefrontal cortex-dorsal anterior cingulate cortex) cortices was strongly associated with a positive CBT outcome. Conclusions: Our results suggest that there are robust neural predictors of CBT outcome in anxiety-related disorders that may eventually lead (probably in combination with other data) to develop personalized approaches for the treatment of these mental disorders.

Matèries

Ansietat, Escorça cerebral, Trastorns de la cognició, Imatges per ressonància magnètica

Matèries (anglès)

Anxiety, Cerebral cortex, Cognition disorders, Magnetic resonance imaging

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Col·leccions

Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)
Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Medicina)

Citació

PICÓ PÉREZ, Maria, FULLANA RIVAS, Miguel àngel, ALBAJES EIZAGIRRE, Anton, VEGA, Daniel, MARCO PALLARÉS, Josep, VILAR, Ana, CHAMORRO, Jacobo, FELMINGHAM, Kim l., HARRISON, Ben j., RADUA, Joaquim, SORIANO MAS, Carles. Neural predictors of cognitive-behavior therapy outcome in anxiety-related disorders: A meta-analysis of task-based fMRI studies. _Psychological Medicine_. 2023. Vol. 53, núm. 8, pàgs. 3387-3395. [consulta: 23 de gener de 2026]. ISSN: 0033-2917. [Disponible a: https://hdl.handle.net/2445/212660]

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