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2023-04-29

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cc-by (c) Llorente, Xavier et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/199761

Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases

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https://doi.org/10.3390/ijms24098053

Resum

Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of themost effective systems for topical drug administration. NLCs are biodegradable, biocompatible and provide a prolonged drug release. The glutamate release inhibitor Riluzole (RLZ) is a drug currently used for amyotrophic lateral sclerosis (ALS), with anti-proliferative effects potentially beneficial for diseases with excessive cell turnover. However, RLZ possesses low water solubility and high light- sensibility. We present here optimized NLCs loaded with RLZ (RLZ-NLCs) as a potential topical treatment. RLZ-NLCs were prepared by the hot-pressure homogenization method using active essential oils as liquid lipids, and optimized using the design of experiments approach. RLZ-NLCs were developed obtaining optimal properties for dermal application (mean size below 200 nm, negative surface charge and high RLZ entrapment efficacy). In vitro release study demonstrates that RLZ-NLCs allow the successful delivery of RLZ in a sustained manner. Moreover, RLZ-NLCs are not angiogenic and are able to inhibit keratinocyte cell proliferation. Hence, a NLCs delivery system loading RLZ in combination with natural essential oils constitutes a promising strategy against keratinocyte hyperproliferative conditions.

Matèries

Nanopartícules, Malalties de la pell

Matèries (anglès)

Nanoparticles, Skin diseases

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Col·leccions

Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

Citació

LLORENTE, Xavier, ESTERUELAS NAVARRO, Gerard, BONILLA VIDAL, Lorena, GARNICA AGUDELO, Mariana, FILGAIRA ENRI, Ingrid, LOPEZ-RAMAJO, Daniel, GONG, Ruoyi c., SOLER PRAT, Concepció, ESPINA GARCÍA, Marta, GARCÍA LÓPEZ, María luisa, MANILS PACHECO, Joan, PUJOL CUBELLS, Montserrat, SÁNCHEZ-LÓPEZ, E. (elena). Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases. _International Journal of Molecular Sciences_. 2023. Vol. 24, núm. 8053. [consulta: 21 de gener de 2026]. ISSN: 1661-6596. [Disponible a: https://hdl.handle.net/2445/199761]

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