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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/199761
Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases
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Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of themost effective systems for topical drug administration. NLCs are biodegradable, biocompatible and provide a prolonged drug release. The glutamate release inhibitor Riluzole (RLZ) is a drug currently used for amyotrophic lateral sclerosis (ALS), with anti-proliferative effects potentially beneficial for diseases with excessive cell turnover. However, RLZ possesses low water solubility and high light- sensibility. We present here optimized NLCs loaded with RLZ (RLZ-NLCs) as a potential topical treatment. RLZ-NLCs were prepared by the hot-pressure homogenization method using active essential oils as liquid lipids, and optimized using the design of experiments approach. RLZ-NLCs were developed obtaining optimal properties for dermal application (mean size below 200 nm, negative surface charge and high RLZ entrapment efficacy). In vitro release study demonstrates that RLZ-NLCs allow the successful delivery of RLZ in a sustained manner. Moreover, RLZ-NLCs are not angiogenic and are able to inhibit keratinocyte cell proliferation. Hence, a NLCs delivery system loading RLZ in combination with natural essential oils constitutes a promising strategy against keratinocyte hyperproliferative conditions.
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LLORENTE, Xavier, et al. Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases. International Journal of Molecular Sciences. 2023. Vol. 24, num. 8053. ISSN 1661-6596. [consulted: 1 of July of 2026]. Available at: https://hdl.handle.net/2445/199761