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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/181697
NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
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Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.
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HUESO VAL, Miguel, MALLÉN, Adrián, SUÑÉ POU, Marc, ARAN PERRAMON, Josep m., SUÑÉ I NEGRE, Josep m. (josep maria), NAVARRO, Estanis. NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery. _International Journal of Molecular Sciences_. 2021. Vol. 22, núm. 21, pàgs. 11596. [consulta: 23 de gener de 2026]. ISSN: 1422-0067. [Disponible a: https://hdl.handle.net/2445/181697]