Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/181697
NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.
Subject
Subject (English)
Citation
Citation
HUESO VAL, Miguel, et al. NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery. International Journal of Molecular Sciences. 2021. Vol. 22, num. 21, pags. 11596. ISSN 1422-0067. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/181697