Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/181697
NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.
Matèries
Matèries (anglès)
Citació
Citació
HUESO VAL, Miguel, et al. NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery. International Journal of Molecular Sciences. 2021. Vol. 22, num. 21, pags. 11596. ISSN 1422-0067. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/181697