NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery

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dc.contributor.authorHueso Val, Miguel
dc.contributor.authorMallén, Adrián
dc.contributor.authorSuñé Pou, Marc
dc.contributor.authorAran Perramon, Josep M.
dc.contributor.authorSuñé i Negre, Josep M. (Josep Maria)
dc.contributor.authorNavarro, Estanis
dc.date.accessioned2021-12-09T08:43:34Z
dc.date.available2021-12-09T08:43:34Z
dc.date.issued2021-10-27
dc.date.updated2021-12-02T08:29:25Z
dc.description.abstractNon-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.
dc.format.extent15 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec718189
dc.identifier.issn1422-0067
dc.identifier.pmid34769025
dc.identifier.urihttps://hdl.handle.net/2445/181697
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/ijms222111596
dc.relation.ispartofInternational Journal of Molecular Sciences, 2021, vol. 22, num. 21, p. 11596
dc.relation.urihttps://doi.org/10.3390/ijms222111596
dc.rightscc by (c) Hueso Val, Miguel et al, 2021
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
dc.subject.classificationNanomedicina
dc.subject.classificationÀcids nucleics
dc.subject.otherNanomedicine
dc.subject.otherNucleic acids
dc.titleNcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))